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The need for re-establishing the "one-health" approach toward managing emerging infectious diseases is becoming increasingly important as the interactions among wildlife, livestock, and humans intensify. These interactions can exacerbate the potential for disease transmission and often lead to emerging and re-emerging infectious diseases in humans and animals.  Diseases such as bovine tuberculosis and brucellosis, rabies, monkey pox, influenza, SARS, and others, have demonstrated the importance for conducting comprehensive surveillance programs that include coordination across animal and human health agencies. The USDA/APHIS Wildlife Services uses a "one-health" approach to investigate bacterial, viral, and parasitic zoonoses in feral swine (Sus scrofa).  This project serves as an appropriate model for the "one-health" approach to manage infectious diseases.  An overview of this comprehensive feral swine disease surveillance project will be discussed.  Results from surveillance in over 35 states will be shared, including a discussion of classical swine fever, brucellosis, influenza, pseudorabies, toxoplasmosis, trichinosis.