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Advanced Very High Resolution Radiometer (AVHRR), Normalized Difference Vegetation Index data (NDVI, 1 km2, 1985-2003) and modeled net primary production (NPP, 8 km2, 1981-2000) data were used to estimate vegetation production in South Africa (SA). The linear relationships of LogeRainfall with NPP and [Sigma]NDVI were calculated for every pixel. Vegetation production generally had a strong relationship with rainfall over most of SA. Therefore, human-induced land degradation can only be detected if its impacts on vegetation production can be distinguished from the effects of rainfall. Two methods were tested (i) Rain-Use Efficiency (RUE=NPP/Rainfall or [Sigma]NDVI/Rainfall) and (ii) Residual Trends (RESTREND), i.e. negative trends in the differences between the observed [Sigma]NDVI and the [Sigma]NDVI predicted by the rainfall. Degraded areas mapped by the National Land Cover in north-eastern SA had reduced RUE; however, annual RUE had a very strong negative correlation with rainfall and varied greatly between years. Therefore, RUE was not a reliable indicator of degradation. The RESTREND method showed promising results at a national scale and in the Limpopo Province, where negative trends were often associated with degraded areas in communal lands. Both positive and negative residual trends can, however, result from natural ecological processes, e.g. the carryover effects of rainfall in previous years. Thus, the RESTREND method can only identify potential problem areas at a regional scale, while the cause of negative trends has to be determined by local investigations.