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Paper presented at the "Symposium on Ingestion of Poisonous Plants by Livestock," February 15, 1990, Reno, Nevada. Improved usage of rangelands for livestock production requires better ways to reduce losses caused by poisonous plants, such as management practices to minimize ingestion and treatments to improve animal tolerance of ingested poisonous plants. In ruminants, gastrointestinal microbes can detoxify plant compounds, and this capacity has been enhanced in a few cases by deliberate modification of rumen microbial populations. Some plants are poisonous because ingested plant material is made toxic by microbial fermentation in the rumen, and better understanding of such toxifications will provide opportunities to diminish poisonings of that type. Absorption of toxic substances from the gastrointestinal tract into blood and lymph may be modified by feeding binding agents such as clay, resins, and indigestible fibers, or by pharmaceuticals that interfere with absorption of toxicants. Agents that induce or inhibit biotransformational enzymes in tissues of the host animal might modify animal tolerance of some plant toxicants. Provision of substances that serve as co-substrates of detoxification can enhance animal tolerance of other types of plant toxicants. Some reports that illustrate these approaches have been reviewed, and questions have been raised to stimulate further research. This material was digitized as part of a cooperative project between the Society for Range Management and the University of Arizona Libraries. The Journal of Range Management archives are made available by the Society for Range Management and the University of Arizona Libraries. Contact lbry-journals@email.arizona.edu for further information. Migrated from OJS platform August 2020