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Restoring western US rangelands from a site dominated by invasive annuals, such as cheatgrass and medusahead, to a diverse, healthy, perennial plant − dominated ecosystem can be difficult with native grasses. This study describes the establishment and trends in persistence (plant/m2) of native grass cultivars and germplasm compared with typically used crested and Siberian wheatgrasses at four locations in Idaho (one), Wyoming (one), and Utah (two) that range in mean average annual precipitation (MAP) from 290 to 415 mm. Sites were cultivated and fallowed 1 yr before planting using two glyphosate applications to control weeds. We monitored seedling establishment of 10 perennial cool-season grass species and plant persistence over 5 yr. Precipitation during the seeding year varied with the Utah sites locations reviving below MAP (4% and 14%), while the Wyoming and Idaho sites received above MAP at 8% and 26%, respectively. Across these four sites, native grass seedling establishment of bottlebrush squirreltail (29 ± 0.08 [standard error] seedling/m2), bluebunch (28 ± 0.05), slender (30 ± 0.05), and Snake River wheatgrasses (28 ± 0.08) was similar to “Vavilov II” Siberian wheatgrass (36 ± 3.20). By yr 5, western, Snake River, and thickspike wheatgrasses were the only native grasses to have plant densities similar to Vavilov II (37 ± 0.29) Siberian and “Hycrest II” (36 ± 0.29) crested wheatgrasses. On sites receiving between 290 and 415 mm MAP, our data suggest that native grasses are able to establish but in general lack the ability to persist except for western, Snake River, and thickspike wheatgrasses, which had plant densities similar to crested and Siberian wheatgrasses after 5 yr.