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Invasive winter annual grasses such as cheatgrass (Bromus tectorum), medusahead (Taeniatherum caput-medusae), and ventenata (Ventenata dubia) are a threat to native ecosystems throughout the US.� Cheatgrass out-competes native vegetation with devastating consequences including more frequent and more intense wildfires, degraded wildlife and pollinator habitat, loss of diversity, and inferior recreation experiences.� For decades, land managers have been attempting to recover cheatgrass dominated sites; however, there are currently limited management options that work consistently, provide multiple years of control, and do not injure desirable plant communities.� While glyphosate, imazapic (Plateau�, BASF), and rimsulfuron (Matrix�, Bayer) are herbicides commonly recommended to control invasive annual grasses, short-term control results in rapid reinvasion of treated areas via the soil seed bank (<5 years).� Indaziflam (Esplanade� 200SC, Bayer) is a cellulose biosynthesis inhibiting (CBI) herbicide that is a unique mode of action for resistance management.� Multiple field studies at Colorado State University have shown Esplanade 200SC provides long-term (3+ years) cheatgrass control with a single application.� In addition, Esplanade 200SC promoted the reestablishment of the co-occurring plant community by increasing perennial grass (36-fold) and forb biomass (5-fold), and plant diversity (richness) over time.� Esplanade 200SC research trials have been conducted throuhgout the western US including Washington State University and Utah State University.� These studies have resulted in >99% ventenata and medusahead control the second year after treatment.� In a greenhouse study, indaziflam applied preemergence was on average 12 times more active than imazapic on six invasive annual grasses including cheatgrass, medusahead, and ventenata.� Indaziflam could potentially be used to eliminate the soil seed bank of these invasive grasses, decrease fine fuel accumulation, and ultimately increase the competitiveness of perennial co-occuring species on western rangelands.� Bayer is currently conducting the studies necessary to establish a grazing tolerance for use on sites grazed by domestic livestock.