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Vinorama or huizache (A. farnesiana) is an aggressive tall-shrub which invades buffelgrass (Cenchrus ciliaris) pastures and reduces productivity. Prado herbicide (621.3 g i.a./kg. Amynopyralid + 94.5 g i.a./kg. Metsulfuron metil) is a new product from Dow Agrosciences in Mexico and no local data is available for its use. This study was conducted in summer of 2011 to evaluate the efficiency of Prado herbicide and manual con�trol by machete to reduce vinorama populations. Treatments applied were: Prado herbicide one doses (75 grams) on 100 liters of water, manual control by machete and the untreated check. Plot 10 by 30 m were used in a randomized complete block design with three treatments and 20 replications. Data was analyzed by ANOVA. Evaluated variables were: brush mor�tality, grass density, plant height, basal cover and forage pro�duction. All variables were evaluated from 2011 to 2013. Prado herbicide controlled 100% of vinorama and caused no phytotoxicity problems to grasses present. Machete treatments controlled 5% of the vinorama plants but treated plants sprouted back and reach pretreatment levels after three summer growing seasons. Chemical brush control increased (P<0.05) grass density, plant height, basal cover and the forage production of both buffelgrass and native grass species. Total forage pro�duction varied from 7.5 to 9.0 metric tons D.M./ha on chemically treated plots, from 6.5 to 6.8 metric tons D.M./ha on machete treat�ed areas and from 4.3 to 4.9 metric tons D.M./ha on the untreated checks. Buffelgrass plots where vinorama was controlled pro�duced additionally from 1.6 to 3.6 metric tons of D.M.ha/year. Man�ual control by machete is not recommended because of low plant control and forage production increases are short-lived and are economically not justified. Foliar applications of Prado herbicide are appropriated to reduce vinorama populations and increase pro�ductivity in buffelgrass pastures in the humid areas of south�ern Sonora, Mexico.