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Honey locust is a deciduous tree that produces large brown seed pods and thorny appendages. Fire suppression and the introduction of honey locust into shelter belts has allowed honey locust to increase in the southern mixed grass prairie region. Because locust trees produce prolific sprouts, mechanically cutting trees seldom results in complete tree mortality. Trees 3-8 inches in diameter were treated with one of five combinations of herbicides and application methods to test for control. Treatment combinations, on a volume:volume basis, included: 1) triclopyr 25% + diesel 75% and 2) aminopyralid 5% + bark oil 95%, both applied to the lower 15 inches of basal bark including the root collar area of live trees, as well as 3) triclopyr 25% + diesel 75%, 4) aminopyralid 10% + water 90%, and 5) dicamba 33% + 2,4-D 2% + water 65%, all applied immediately to the outer cambium layer of cut stumps. One year after treatment, aminopyralid applied as a basal bark or as a cut stump treatment had the best control and averaged over 97% dead trees. The triclopyr + diesel cut stump treatment had fewer dead trees (just over 50%) than any other treatment and produced many new sprouts. In grazed pasture, treating stumps with aminopyralid + water and treating standing trees with a basal bark application of aminopyralid + oil were two effective control options. Triclopyr + diesel was better at controlling live standing trees with a basal bark treatment rather than as a cut stump treatment.