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Sendero� herbicide (aminopyralid + clopyralid) was introduced to the southwest USA in 2012 as The New Standard For Mesquite Control�.� In south Texas, mesquite (Prosopis glandulosa) is often a component of a mixed brush complex of hard to control woody species.� In other parts of Texas, honeylocust (Gleditsia triacanthos) is a common invader of rangelands and pastures, displacing native vegetation and decreasing desirable forage production.� In 2013 and 2014 a series of experiments (n=4) were conducted in south Texas to investigate the tank mixes of Sendero plus Tordon� 22K or Remedy� Ultra in aerial applications.� Evaluations were made to determine apparent mortality of species typically found in the south Texas mixed brush complex.� Concurrently, a series of experiments (n=4) were conducted in north central Texas to evaluate Sendero and other herbicides for control of honeylocust with aerial applications on rangelands.� Mortality data from 1 and 2 years after treatment indicate that tank mixes of Sendero with Tordon or Remedy Ultra show equal to or better control of all brush species (including catclaw acacia, blackbrush acacia, granjeno, guajillo, huisache, huisachillo, lotebush, and mesquite) compared to Sendero alone.� Sendero tank mixes are equivalent or better to current tank mix recommendations for mesquite and south Texas mixed brush.� In the north Texas aerial broadcast herbicide trials, Sendero at 28 fl oz/ac resulted in an average of 80% apparent mortality of honeylocust and provided selectivity of control, leaving most other hardwoods unharmed. Aerial applications of Sendero resulted in significantly better control than current industry standards for chemical application.� This research further demonstrates the utility of Sendero herbicide in southwestern US brush management.